TRPV1

TRPV1
Identifiants
Aliases	TRPV1
IDs externes	OMIM: 602076 MGI: 1341787 HomoloGene: 12920 GeneCards: TRPV1
Position du gène (Homme) Chr. Chromosome 17 humain[1] Locus 17p13.2 Début 3,565,444 bp[1] Fin 3,609,411 bp[1]
Position du gène (Souris) Chr. Chromosome 11 (souris)[2] Locus 11 B4|11 45.25 cM Début 73,125,118 bp[2] Fin 73,152,068 bp[2]
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans right lobe of liver nerf sural apex of heart cerebellar hemisphere right hemisphere of cerebellum right uterine tube gonade left ovary right ovary endocol Fortement exprimé dans lumbar spinal ganglion Ganglion de Gasser morula glossopharyngeal ganglion blastocyste embryon spermatocyte tissu adipeux blanc œsophage lèvre Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire liaison nucléotide ion channel activity phosphoprotein binding liaison ATP cation transmembrane transporter activity cation channel activity ligand-gated ion channel activity calcium-release channel activity temperature-gated ion channel activity identical protein binding chloride channel regulator activity transmembrane signaling receptor activity excitatory extracellular ligand-gated ion channel activity calcium channel activity extracellular ligand-gated ion channel activity phosphatidylinositol binding liaison ion métal fixation de la calmoduline liaison protéique Composant cellulaire integral component of membrane membrane postsynaptique prolongement cellulaire membrane membrane plasmique synapse jonction cellulaire dendritic spine membrane cytosol neuronal cell body intrinsic component of plasma membrane dendrite external side of plasma membrane neuron projection integral component of plasma membrane mitochondrie Processus biologique ion transport chemosensory behavior cell surface receptor signaling pathway calcium ion transmembrane transport thermoception calcium ion transport réponse inflammatoire transport transmembranaire release of sequestered calcium ion into cytosol negative regulation of transcription by RNA polymerase II diet induced thermogenesis detection of chemical stimulus involved in sensory perception of pain microglial cell activation cellular response to growth factor stimulus positive regulation of gastric acid secretion response to peptide hormone cellular response to nerve growth factor stimulus positive regulation of nitric oxide biosynthetic process negative regulation of establishment of blood-brain barrier processus métabolique lipidique temperature homeostasis response to heat cellular response to temperature stimulus positive regulation of cytosolic calcium ion concentration peptide secretion detection of temperature stimulus involved in sensory perception of pain sensory perception of mechanical stimulus smooth muscle contraction involved in micturition behavioral response to pain response to pain cellular response to alkaloid cellular response to cytokine stimulus fever generation detection of temperature stimulus involved in thermoception positive regulation of apoptotic process urinary bladder smooth muscle contraction glutamate secretion nociception cellular response to tumor necrosis factor cellular response to ATP ion transmembrane transport response to pH response to organonitrogen compound cellular response to heat protein homotetramerization Potentiel postsynaptique excitateur cellular response to acidic pH response to capsazepine calcium ion import across plasma membrane negative regulation of systemic arterial blood pressure negative regulation of heart rate negative regulation of mitochondrial membrane potential Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 7442 193034 Ensembl ENSG00000196689 ENSMUSG00000005952 UniProt Q8NER1 Q704Y3 RefSeq (mRNA) NM_018727 NM_080704 NM_080705 NM_080706 NM_001001445 RefSeq (protéine) NP_061197 NP_542435 NP_542436 NP_542437 NP_001001445 Localisation (UCSC) Chr 17: 3.57 – 3.61 Mb Chr 11: 73.13 – 73.15 Mb Publication PubMed [3] [4]
Wikidata
Voir/Editer Humain Voir/Editer Souris

Les récepteurs TRPV1 (sigle anglais pour transient receptor potential vanilloide 1) sont des récepteurs ionotropes activés par des molécules de la famille des vanilloïdes (V) telle que la capsaïcine présente dans le piment. Ces récepteurs interviennent dans les mécanismes nociceptifs et s'activent en réponse à un stimulus thermique (Thermosensation) supérieur à 44 °C.